Department of Organic Chemistry

Study place:	Department of Organic Chemistry, FCT, VŠCHT Praha
Guaranteeing Departments:	Department of Organic Chemistry
Study Programme/Specialization:	Drugs and Biomaterials ( in English language )
Supervisor:	prof. Andrea Brancale, Ph.D.
Expected Form of Study:	Combined
Expected Method of Funding:	Not funded

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This industrial PhD merges Cheminformatics, AI, and NMR to transform drug discovery. The candidate will refine AI|ffinity’s NMR-AI platform for virtual screening, hit discovery, and hit-to-lead optimization. Their focus includes: (1) enhancing 2D molecular representations using 1D NMR spectra to boost ligand-based virtual screening, (2) refining AI-driven structure-based hit-to-lead workflows harnessing 1D NMR restraints, and (3) innovating de novo design by integrating ligand epitope data from 1D NMR experiments. The candidate will also embed deep learning-powered screening and de novo generation into a reinforcement learning system, extracting ligand epitope information from 1D NMR data to identify novel bioactive molecules and to search commercial libraries. Promising compounds will be experimentally validated, driving iterative refinement and synthesis. The best leads advance toward in vitro assessment, and all newly developed computational methods will be integrated into AI|ffinity’s Drug Discovery platform.

Study place:	Department of Organic Chemistry, FCT, VŠCHT Praha
Guaranteeing Departments:	Department of Organic Chemistry
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	prof. Ing. Pavel Lhoták, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary

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The aim of this work is focused on the design and synthesis of higher calixarenes (with five or more phenolic subunits) and their analogues, that could be applied as receptors for fullerene recognition. The aim of this work is to achieve selective complexation of C60 or C70 using suitably chemically modified calixarene skeletons and concave/convex principle of the interactions. Novel compounds will be used not only as receptors for fullerene complexation, but also for the construction of more sophisticate supramolecular systems (e.g. self-assembly).

Study place:	Department of Organic Chemistry, FCT, VŠCHT Praha
Guaranteeing Departments:	Department of Organic Chemistry
Study Programme/Specialization:	Chemistry ( in Czech language )
Supervisor:	prof. Ing. Michal Kohout, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Salary

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High performance liquid chromatography (HPLC) is the world’s leading method for separation of chemical mixtures. Despite undoubtful progress in numerous areas of this field in recent years, resolution of polar ionised and ionisable analytes still represents a very challenging task to solve. Moreover, most advancements achieved are of purely academic nature and are not transferred into any actual technology used in practice. The present Ph.D. project covers the full scope of research and development of a new portfolio of brush-type stationary phases bearing ion-exchange selectors intended for both chiral and achiral separations of ionised and ionisable compounds. The candidate is expected to synthesise a new library of cation exchangers (CX), anion exchangers (AX) and zwitterion ion exchangers (ZW) derived from natural precursors (e.g., cinchona alkaloids, amino acids, etc.). The prepared selectors will be immobilised to silica gel solid support and tested as separation media for various sets of analytes (e.g., amino acids, organic acids, basic drugs, short peptides, etc.). In collaboration with our laboratory spinoff - Galochrom s.r.o., the synthesis of the stationary phases with the best separation performance will be scaled-up and marketed as a part of the new generation of Galochrom’s product portfolio. Therefore, a direct industrial impact of the Ph.D. project is expected.

Study place:	Department of Organic Chemistry, FCT, VŠCHT Praha
Guaranteeing Departments:	Department of Organic Chemistry
Study Programme/Specialization:	Chemistry ( in Czech language )
Supervisor:	doc. Ing. Tomáš Tobrman, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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This work focuses on the synthesis of novel polydentate phosphane ligands containing at least four phosphorus centers. The complexation properties of the resulting ligands will be thoroughly investigated. The primary applications of these ligands will include the selective isolation of noble metals (Rh, Pd, Au) from natural sources and their use in cross-coupling reactions.

Study place:	Department of Organic Chemistry, FCT, VŠCHT Praha
Guaranteeing Departments:	Department of Organic Chemistry
Study Programme/Specialization:
Also available in study programmes:	Chemistry ( in Czech language ), Chemistry ( in English language )
Supervisor:	Ing. Petr Kovaříček, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary

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Hydrogen is considered as primary option in our transition to climate neutral economy. However, current technologies of hydrogen production are far from being climate neutral. Moreover, they involve pricy and precious materials that the EU must import from countries, which use those materials as geopolitical leverage. In this project, we will research the technology of hydrogen production using light (i.e. green hydrogen) and sustainable all-organic thin films and conjugated polymers. The project will integrate organic synthesis with materials preparation and extensive characterization, up to device assembly and testing in selected catalytic transformations with particular focus on green hydrogen photoelectrochemical cells.

Study place:	Department of Organic Chemistry, FCT, VŠCHT Praha
Guaranteeing Departments:	Department of Organic Chemistry
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	prof. Ing. Pavel Lhoták, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary

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Pillar[n]arenes can be considered relatively new members of the family of phenolic macrocycles. Due to their unique cylindrical shape and electron-rich cavity, pillar[n]arenes have already found many applications in contemporary supramolecular chemistry. To name at least a few such applications, the sensing of various analytes, supramolecular self-assemblies, stimuli-responsive supramolecular polymers and model systems to study various noncovalent interactions can be mentioned. It is well known from the chemistry of calix[n]arenes that the introduction of sulfur instead of common methylene bridges leads to dramatic changes in chemical and supramolecular behaviour of such systems. Recently, it has been shown that these compounds can be constructed using the 1,4-conjugate addition of suitable building blocks. The aim of this project is the construction of pillararenes and their analogues bearing heteroatoms as the bridging units and the investigation of these new macrocycles including their characterization, derivatization and the study of supramolecular applications.

Study place:	Department of Organic Chemistry, FCT, VŠCHT Praha
Guaranteeing Departments:	Department of Organic Chemistry
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Ing. Martin Tlustý, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary

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Porous crystalline materials are used for the gas separation and storage, catalysis or chemical sensing. Their properties are strongly related to their porosity. However, one of the problems preventing the preparation of highly porous materials is the interpenetration – the interweaving of multiple crystal lattices. The aim of the project is to use the mechanical bond as a protecting group to prevent the interpenetration and, thus, the preparation of highly porous materials.

Institute of Chemical Process Fundamentals of the CAS

Study place:	Institute of Chemical Process Fundamentals of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Chemical Process Fundamentals of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Mgr. Jindřich Karban, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Important aspects in the design of carbohydrate-based therapeutics and materials are their conformational properties, which are partly determined by intramolecular hydrogen bonds (H-bonds). To achieve the desired properties of these compound classes, regio- and stereoselective introduction of fluorine is used. However, the influence of fluorine on the intramolecular H-bonds in oligosaccharides formed by functional groups vicinal to fluorine has not been investigated. The aim of this project is to investigate this influence and to elucidate the conformation of selected fluorinated oligosaccharides. Fluorinated disaccharides derived from N-acetyllactosamine and fluorinated trisaccharides derived from the Lewis X antigen (LewisX) will be synthesized and used to study inter-residue H-bonds including the non-conventional H-bond, which stabilizes LewisX. A combination of computational approaches and NMR experiments will be used to elucidate the conformational states and to detect and evaluate intramolecular H-bonds. Required education and skills • Master degree in chemistry. • The willingness to learn and apply advanced methods of organic synthesis and structure elucidation.

Study place:	Institute of Chemical Process Fundamentals of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Chemical Process Fundamentals of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Dr. Ing. Vladimír Církva
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Many synthetic strategies attempt to vary the shape and size of the π-conjugated system of aromatic compounds to obtain optimal properties. Recently, an alternative approach has come to the fore, which introduces a heteroatom (phosphorus) into the aromatic backbone, whose specific properties (chiral center on phosphorus, easy change of oxidation state, possibility of derivatization) significantly influence the behavior of the π-framework. This project deals with developing a simple and efficient preparation that introduces phosphorus hexacycles into aromatic structures. The aim is to apply this approach to synthesizing polyaromatic compounds such as phenacenes, helicenes, or nanographenes containing phosphorus atoms. Required education and skills: • master's degree in organic chemistry, • experimental skill and practical knowledge of organic synthesis, • teamwork ability, • employment contract at ICPF.

Study place:	Institute of Chemical Process Fundamentals of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Chemical Process Fundamentals of the CAS
Study Programme/Specialization:	Drugs and Biomaterials ( in English language )
Supervisor:	Ing. Tomáš Strašák, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The project is focused on the application of modular synthesis principles to a preparation of novel dendritic materials with properties tailored for medicinal applications, especially in the field of regenerative medicine. The first stage comprises the synthesis of a library of carbosilane building blocks (dendrons) using silicon atom as a branching point and bearing suitable peripheral functional groups (saccharide ligands, cationic groups, PEGyl chains etc.). These components will then be used for the construction of multifunctional macromolecular compounds with precisely defined dendritic structure. The application of prepared materials to the encapsulation of small molecule drugs, complexation of therapeutically active proteins and growth factors, and physically-chemical characterization of these systems will be an inherent part of the work, with emphasis on suitable pharmacokinetic and cytotoxic behavior. The work is a part of the research project supported from OP JAK fund; within this project the student will closely collaborate with external partners on the application of the prepared materials. Required education and skills • Master degree in organic chemistry, organic technology; • enthusiasm for experimental work and learning of new things; • team work ability.

Study place:	Institute of Chemical Process Fundamentals of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Chemical Process Fundamentals of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Mgr. Jindřich Karban, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Galectins are a class of lectins (carbohydrate-binding proteins other than enzymes and antibodies) characterized by affinity to some galactosides and sequence homology. Non-covalent interactions of galectins with oligosaccharides are involved in many fundamental biological events. Inhibition of these interactions by synthetic analogs of endogenous saccharide agonists (glycomimetics) is of principal significance for their study and for drug development. The main goal of this PhD project is the synthesis and evaluation of hybrid glycomimetic galectin inhibitors based on the combination of carbohydrate and organometallic structural motifs. The incorporation of an organometallic moiety into the structure of a glycomimetic inhibitor can not only result in higher affinity or selectivity of inhibition, but also allow the study of interactions with galectins by electrochemical methods. The presence of the transition metal in the inhibitor molecule also expands the possibilities of its detection in cells and tissues. Required education and skills • Master degree in chemistry. • The willingness to acquire and apply advanced methods of organic synthesis.

Study place:	Institute of Chemical Process Fundamentals of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Chemical Process Fundamentals of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Mgr. Jindřich Karban, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Galectins are a class of lectins (carbohydrate-binding proteins other than enzymes and antibodies) characterized by affinity to galactosides and sequence homology. So-called tandem galectins comprise two related but non-identical carbohydrate-binding domains (CRD) with partially different substrate specificities. Inhibition of tandem galectins by synthetic analogs of saccharides (glycomimetics) is of great importance in both fundamental research and drug development. The attachment of monovalent domain-specific inhibitors to suitable carriers will result in multivalent inhibitors that can inhibit both domains within the tandem galectin simultaneously and very effectively, if the right topology is achieved. The main goal of this PhD project is the synthesis and evaluation of glycomimetic inhibitors of individual domains and the verification of the hypothesis that an appropriate spatial arrangement of domain-specific inhibitors on a multivalent carrier can lead to high affinity inhibitors of tandem galectins due to a multivalent effect. Required education and skills • Master degree in chemistry. • The willingness to learn and apply advanced methods of organic synthesis.

Institute of Macromolecular Chemistry of the CAS

Study place:	Institute of Macromolecular Chemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Macromolecular Chemistry of the CAS
Study Programme/Specialization:	Drugs and Biomaterials ( in English language )
Supervisor:	RNDr. Petr Chytil, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Polymer drug carriers are non-toxic, non-immunogenic, and biocompatible polymer materials that target and control the release of biologically active compounds in the treated tissue, thus minimizing the side effects of carried drugs. The doctoral project theme will consist of synthesizing and studying the properties of tailor-made hydrophilic or amphiphilic polymers that are efficient as anti-cancer drug carriers. The theme is suitable for graduates of chemistry and, eventually, pharmacy. The student will learn new skills in the synthesis and characterization methods and can participate in biological characterization in internal or international cooperating laboratories. We offer exciting and varied work in a well-established team of Biomedical polymers, affording hi-tech equipment and material background.

Institute of Organic Chemistry and Biochemistry of the CAS

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Dr. habil. Ullrich Jahn
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The axinellamines belong to the most complex alkaloids with interesting biological properties. With this project biomimetic approaches will be explored to enable short total syntheses of the natural products themselves and of analogs. Their biological profile will be investigated in collaboration.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Dr. Paulo Paioti
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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We recently developed a method for synthesis of otherwise difficult-to-access atropisomers by nucleophilic aromatic substitution. One advantage is that starting materials, N‒H heterocycles and fluoroarenes, are readily available, and another is that the reactions are highly efficient and broadly applicable. However, the method currently produces racemates of atropisomers and is not catalytic. Accordingly, PhD students in our laboratory will develop catalytic atroposelective synthesis of such compounds and others. Several possibilities will be studied. The molecules synthesized in this project will be tested broadly in medicinal chemistry screenings.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Drugs and Biomaterials ( in English language )
Supervisor:	Mgr. Radim Nencka, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The Ph.D. student will design and synthesise novel methyltransferase (MTase) inhibitors targeting viral, fungal or human MTases. The student will use in silico approach to speed up the development of potential drugs, but the main part of the assignment will be the organic synthesis. Preparation of suitable ligands bearing a fluorescent tag will enable the efficient development of a screening assay.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	RNDr. Tomáš Slanina, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Photoinduced electron transfer and charge separation is one of the most important phenomena in Universe. It plays an important role in processes essential for life, such as photosynthesis, respiration, protein folding and biocatalysis. It is also highly relevant for solar cells, batteries, molecular electronics and smart materials. The thesis will focus on development of systems for reversible charge transfer between two redox-active centres. The transfer of charge will be in both directions controlled by photoinduced electron transfer and both states will be stabilized by follow-up chemical reaction (intramolecular cyclization, protonation and others). Reversible photoinduced electron transfer will be used for dipole reorientation, control of charges and counterions and regulation of electrostatic interactions. These unique properties will be further used in design of novel materials and devices in molecular electronics. The candidate will perform synthesis and characterization of organic redox-active molecules and will study their properties. Highly motivated and skilful candidate will have the opportunity to extend his/her graduate training in physical and organic chemistry by learning electrochemical, photochemical and advanced spectroscopic methods.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	prof. Ing. Michal Hocek, DSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Nucleotides bearing specific ligands or reactive groups will be designed and synthesized, from which modified DNA will be synthesized by enzyme methods and used to attach target proteins. Applications will include multi-enzyme systems.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	prof. Ing. Michal Hocek, DSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Modified 2'-deoxyribonucleoside-triphosphates will be synthesized and used in enzymatic synthesis of oligodeoxyribonucleotides and DNA bearing several modifications at specific positions using a novel approach involving repeated annealing of RNA templates, primer extension and RNA digestion. Applications will include the spatially defined attachment of several different biomolecules, particularly proteins, to DNA.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Dr. habil. Ullrich Jahn
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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We just accomplished approaches to glycine alkoxyamines, which hold large promise in bioconjugation. With this project the potential of these non-natural amino acid derivatives for approaching new peptide architectures will be explored.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	RNDr. Ivo Starý, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The goal of the PhD project will be the development of new helically chiral metal complexes to be explored in enantioselective catalysis. The attention will be paid to the synthesis of cyclometallated helicenes and helical cyclopentadienyl complexes. They will be applied to selected enantioselective reactions catalysed by transition metals such as alkyne cycloisomerisation, olefin metathesis or hydrogenation.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Drugs and Biomaterials ( in English language )
Supervisor:	Mgr. Radim Nencka, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The PhD student will focus on the design and organic synthesis of new methyltransferase inhibitors, whether derived from viral, fungal, or human sources. In the course of developing these compounds, the candidate will employ in silico molecular modeling to streamline and accelerate the search and optimization of inhibitors. Nonetheless, the main emphasis of the project will remain on the organic synthesis of potential therapeutic agents. Additionally, the project will include the preparation of ligand analogs equipped with suitable tags, whether fluorescent or functional (e.g., biotin for pull-down assays, thalidomide for PROTAC technology).

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Mgr. Jiří Kaleta, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The project focuses on the development and study of special light-switchable organic molecules that mimic the function of biological systems. These synthetic "molecular machines" will be composed of various photoswitches and molecular motors, with their individual components selectively switched or activated using light of specific wavelengths. The primary goal of the Ph.D. project is the preparation and detailed investigation of these unique molecules and their potential application in the construction of functional prototypes of molecular machines. Emphasis will be placed on different combinations of photoswitches and the methods of their interconnection (orthogonal vs. non-orthogonal).

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Ing. Zlatko Janeba, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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In medicinal chemistry, heterocyclic moieties represent important pharmacophores of various biologically active compounds. The goal of this project will be synthesis and structural optimization of novel heterocyclic compounds with potential anticancer properties, and evaluation of their biological properties (activity, ADME, etc.).

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Mgr. Tomáš Pluskal, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Our lab combines cutting-edge experimental (e.g., LC-MS, metabolomics, RNA-seq) and computational (e.g., bioinformatics, molecular networking, machine learning) approaches to develop new workflows for the discovery and utilization of bioactive molecules derived from plants. The aim of this project will be the development of methods for structural analysis of small molecules isolated from plants using the technique of crystalline sponge X-ray diffraction. The applicants for this position should already have laboratory experience with small molecule crystallography.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	RNDr. Tomáš Slanina, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Electrophiles and Lewis acids are among the most common intermediates utilized for catalytic reactions. Many attempts have been made to characterize and classify the strength and reactivity of these electron deficient species. However, the classical concept of electrophilicity and Lewis acidity starts to fall apart when open-shell (radicals, radical ions) and excited states are considered. The thesis will focus on development of electrophilic systems with open-shell and electronically excited electronic structure capable of various non-classical interactions with nucleophilic and radical partners. This unique behaviour will not only be applied in novel catalytic reactions but if will be used in re-formulation of rules for chemical bonding between open-shell and electronically excited species. The candidate will perform synthesis and characterization of organic non-classical electrophiles and Lewis acids and will study their catalytic properties and non-covalent interactions. Highly motivated and skilful candidate will have the opportunity to extend his/her graduate training in organic chemistry by learning electrochemical, photochemical and physicochemical methods.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	RNDr. Ivo Starý, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The aim of the project is to prepare new helical TADF and excimer luminophores derived from helicenes and to study their chiroptical properties in solution and thin films (in particular circularly polarized luminescence) in order to identify suitable materials for future CP-OLED design.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Ing. Zlatko Janeba, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The goal of the project will be synthesis and structural optimization of novel antiviral compounds, and evaluation of their biological as well as pharmacokinetic properties (in collaboration with other scientific groups as virology and biochemical pharmacology). Suitable prodrugs will be prepared and studied, if necessary.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Dr. habil. Ullrich Jahn
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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With the project, synthetic approaches to complex indoloterpene and their analogs displaying wide-ranging biological activity will be developed.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	RNDr. Irena G. Stará, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The aim of the project is to develop the synthesis of new warped and chiral nanocarbons such as helical pi-conjugated macrocycles, circulenes and cycloarenes. The chiral substances will be prepared in optically pure form by resolution of racemates or by asymmetric synthesis. Their (chir)optical properties, self-assembly in 2D/3D space, aromatic character and their conformational or redox behaviour will be studied in order to identify their possible applications in chemistry or nanoscience.